ncRNA name | hsa-miR-34a |
ncRNA Category | miRNA |
Disease name | age-related cataract |
Species | Homo sapiens |
Tissues/Cell_line | lens epithelium samples; SRA01/04 |
Methods | qRT-PCR, transfection, flow cytometry, luciferase reporter assay |
Expression pattern | up-regulated |
Functional description | MicroRNA-34a is increased in the cataractous lens and triggers mitochondria-mediated apoptosis and oxidative stress by suppressing Notch2. |
PubMed ID | 29299142 |
Year | 2017 |
Title | MicroRNA-34a promotes mitochondrial dysfunction-induced apoptosis in human lens epithelial cells by targeting Notch2. |
Drug-related ncRNA | NO |
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